ADULT HUMAN GLIOBLASTOMAS HARBOR RADIAL GLIA-LIKE CELLS

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Adult Human Glioblastomas Harbor Radial Glia-like Cells

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Summary: Radial glia (RG) cells are the first neural stem cells to appear during embryonic development.Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers.The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner.

Single-cell RNA sequencing analyses of glioblastoma cells reveal transcriptionally dynamic clusters of RG-like cells that share the profiles of normal human fetal viqua-f4 radial glia and that reside in quiescent and cycling states.Functional assays show a role for interleukin in triggering exit from dormancy into active cycling, suggesting a role for inflammation in tumor progression.These data are consistent with the possibility of persistence of RG into ut solution gel for cats adulthood and their involvement in tumor initiation or maintenance.

They also provide a putative cellular basis for the persistence of normal developmental programs in adult tumors.: Tabar and colleagues report that adult brain tumors comprise neoplastic radial glia-like cells reminiscent of normal radial glia of early development.They are responsive to inflammation signals and may represent putative stem cells of origin of this lethal tumor.

Keywords: radial glia, cancer stem cells, glioblastoma, inflammation, brain tumor, scRNASeq, tumor mitosis.

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